So there’s this thing called the plague.
You’ve probably heard of it. It’s pretty famous, as pandemics go.
Apparently remaking movies and fashion trends has been so successful that now we’re doing it with diseases. I mean, why reinvent the wheel???
And here’s what it looks like:
Whoa, it’s the Cheshire Cat version.
So should we be pretty freaked out? I mean we all learned about the BLACK DEATH in school. Thank goodness it’s been eradicated, because that would be really terrifying.
Oh wait…turns out a few people get the plague every year.
Plague in the United States
Over 80% of United States plague cases have been the bubonic form. In recent decades, an average of seven human plague cases have been reported each year (range: 1–17 cases per year). Plague has occurred in people of all ages (infants up to age 96), though 50% of cases occur in people ages 12–45. It occurs in both men and women, though historically is slightly more common among men, probably because of increased outdoor activities that put them at higher risk.
Ummm….WHOA. MEN have increased outdoor activities?!?!?!
CDC, to be honest, I’m feeling a little triggered here.
Or should I say, CPC… Center for Patriarchal Control. 😂 That was a joke.
Anyway….two people got sick and died of a thing that we all learned to be super scared of in elementary school.
And we’ve been receiving some messaging that the next “pandemic” is coming and stuff.
Which I’ve written about before ⇩
After our most recent installation of totalitarian control “pandemic”, I think we can all agree that there will be a solution conveniently ready to roll out, right? You know, to “fix” the next BIG THING.
It’s hard to know which one’s going to have legs, because there’s just so much preparedness (see links above).
This morning when my first two clients brought up the plague, I immediately looked into it. I made a quick video of what’s being peddled.
But what do you know….there’s vaccine activity on the plague horizon. PHEW!
Plague Vaccine
(This is the old school one)
PLAGUE VACCINE
Plague vaccines ** have been used since the late 19th century, but their effectiveness has never been measured precisely. The degree of protection afforded against primary pneumonic infection is not known. Persons exposed to plague patients who have pneumonia or to Yersinia pestis *** aerosols in the laboratory should be given a 7- to 10-day course of antimicrobic therapy regardless of vaccination history. Recommended antimicrobials include tetracyclines, chloramphenicol, or streptomycin.
The plague vaccine licensed for use in the United States is prepared from Y. pestis organisms grown in artificial media, inactivated with formaldehyde, and preserved in 0.5% phenol. The vaccine contains trace amounts of beef-heart extract, yeast extract, agar, and peptones and peptides of soya and casein.
Following the primary series of 3 injections, about 7% of individuals do not produce PHA antibody, and a few fail to develop a titer of 128, the level correlated with immunity in experimental animals. PHA titers should be determined for individuals who have an unusually high risk of infection or who have a history of serious reactions to the vaccine in order to govern the frequency of booster doses. Such testing can be arranged through state health departments. Since plague vaccination may only ameliorate illness, whenever a vaccinated person has a definite exposure, prophylactic antibiotics may be indicated whether or not an antibody response has been demonstrated.
Soooo….basically it doesn’t work. Got it.
Don’t worry though. The murderers of the world won’t let their abject failure stop them now.
And they got right on it at the WHO Plague Vaccine Workshop that was conveniently held in 2018.
Plague vaccine: recent progress and prospects
Recently, the WHO conceptualized a Plague Vaccine Target Product Profile (TPP) at the WHO Plague Vaccine Workshop in 2018. In this map, there exists at least 17 plague vaccine candidates in the pipeline, including subunit (F1/V-based with adjuvant), bacterial vector-based (e.g., OMV-delivered, Salmonella-expressed), viral vector-based (e.g., Ad5-based, Chad-based), E. coli T4 bacteriophage-based, and live attenuated (e.g., Y. pseudotuberculosis-based or Y. pestis-based) vaccines expressing one or several primary antigens of Y. pestis (e.g., F1 capsular protein antigen, LcrV antigen, YscF antigen, and/or pesticin coagulase), which have been tested in different animal models. Two of these candidates have completed a Phase 2 clinical trial and are moving toward FDA licensure, and several candidates have plans to enter clinical trials in 2019.
First up:
A new generation needle- and adjuvant-free trivalent plague vaccine utilizing adenovirus-5 nanoparticle platform
A plague vaccine with a fusion cassette of YscF, F1, and LcrV encoding genes in an adenovirus-5 vector (rAd5-YFV) is evaluated for efficacy and immune responses in mice. Two doses of the vaccine provides 100% protection when administered intranasally against challenge with Yersinia pestis CO92 or its isogenic F1 mutant in short- or long- term immunization in pneumonic/bubonic plague models.
When The Science™ says 100% protection, you can be sure that it’s,
💥 100% AWESOME SCIENCE 💥
A self-amplifying RNA vaccine provides protection in a murine model of bubonic plague
This saRNA vaccine for plague has the potential for further development, particularly since its amplifying nature can induce immunity with less boosting. It is also amenable to rapid manufacture with simpler downstream processing than protein sub-units, enabling rapid deployment and surge manufacture during disease outbreaks.
Excitement. With some unfortunate setbacks, however it wasn’t the vaccine 🤣:
After immunization and before boosting and subsequent challenge, there were some spontaneous single deaths in some groups, i.e., on day 3 (group 1), on day 7 (group 2), on day 8 (negative control group 7), on day 17 (group 4), and on day 38 (alhydrogel negative control group 8) (Table 2). These deaths occurred in the RNA-negative and alhydrogel control groups as well as in the immunized groups and were not chronologically related to the procedure or a vaccine. At post-mortem, spleen homogenates from the affected animals were cultured on CIN agar and in BHI medium, and none showed typical Y. pestis colonies (Table 4). The individual mice that died pre-challenge in groups except group 7 showed Gram-negative colony growth on CIN agar. E. coli was confirmed by MALDI-TOF in the individual mouse from group 8.
Hey CHECK THIS OUT!
Recently, a mRNA vaccine based on a circularly permutated F1 has been reported to provide 100% protective immunity in mice against the fully virulent Y. pestis KIM53 (100LD50) in the bubonic model (Kon et al., 2023)
Let’s have a look at this beautiful, elegant technology with 100% efficacy.
A single-dose F1-based mRNA-LNP vaccine provides protection against the lethal plague bacterium
2023 Mar 10;9(10):eadg1036.
doi: 10.1126/sciadv.adg1036. Epub 2023 Mar 8.
Plague is a rapidly deteriorating contagious disease that has killed millions of people during the history of humankind. Now, the disease is treated effectively with antibiotics; however, in the case of a multiple-antibiotic-resistant strain outbreak, alternative countermeasures are required. Our mRNA-LNP vaccine elicited humoral and cellular immunological responses in C57BL/6 mice and conferred rapid, full protection against lethal Y. pestis infection after a single dose. These data open avenues for urgently needed effective antibacterial vaccines.
I loved the part of the study when they said this:
Now, over a dozen Fc fusion products have been approved by the Food and Drug Administration and European Medicines Agency for use in the clinic (47). The immunological benefits described above may account for the SP-cp-caf1-hFc–mediated robust humoral response, even when the expressed protein is shuttled via secretory pathways. The mechanisms underlying the differential immune responses between the mRNA constructs remain to be elucidated.
(Psst…That last part means they don’t know)
And this part:
A major limitation in mRNA-LNP vaccines is the inherent instability of mRNA molecules and the resulting requirement for cold (−20°C) or ultracold (−70°C) shipping and storage. In addition, as suggested in the current study, the expression of bacterial proteins in a mammalian system can lead to the production of proteins that may undergo different PTMs, potentially altering the immunogenicity of the original bacterial antigen.
Ok. They just nonchalantly threw out an acronym (PTM) like it’s NBD.
(whispers….it is a big deal)
PTM
Protein Posttranslational Modifications
By changing the protein conformation, localization, activity, stability, charges, and interactions with other biomolecules, PTMs ultimately alter the phenotypes and biological processes of cells.
The homeostasis of protein modifications is important to human health. Abnormal PTMs may cause changes in protein properties and loss of protein functions, which are closely related to the occurrence and development of various diseases.
Accordingly, attention should be paid to ensuring rational and optimal design of the relevant bacterial antigen for induction of a robust and effective immune response. Therefore, we believe that the data presented in this study provides a framework for other antibacterial mRNA-LNP vaccines in the future. These findings are of substantial relevance and immense importance, considering the global emerging crisis of antibiotic resistance and the lack of effective conventional therapies and vaccine candidates.
Let me summarize:
We weren’t totally clear on what happened and why, we know that mRNA is unstable af, and that bacterial protein expression in mammals is pretty dicey…which is why we believe this study should be used for other BATSHIT FUCKING CRAZY HERD CULLING MURDER SHOTS antibacterial mRNA-LNP injections moving forward.
Now let’s check out the acknowledgments.
Acknowledgments
E.K. thanks the Yoran Institute for Human Genome Research for support. We thank R. Rosenfeld for helpful discussions and O. Mazor and S. Yitzhaki for support throughout the study. We thank the Biotechnology Department at IIBR for providing the rF1 protein. We thank I. A. Ionita and D. Danino from the CryoEM Laboratory of Soft Matter, Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel for help in the cryo-EM imaging and analysis.
Funding: This work was supported by ERC LeukoTheranostics award 647410 (to D.P.), EXPERT European Union’s Horizon 2020 research and innovation programme award 825828 (to D.P.), the Shmunis Family Foundation award (to D.P.), and Israel Institute for Biological Research grant number SB-157 (to E.M. and O.C.).
Competing interests: D.P. declares the following competing financial interest(s): D.P. receives licensing fees (to patents on which he was an inventor) from, invested in, consults (or on scientific advisory boards or boards of directors) for, and lectured (and received a fee) or conducts sponsored research at TAU for the following entities: ART Biosciences, BioNtech SE, Kernal Biologics, Merck, Newphase Ltd., NeoVac Ltd., RiboX Therapeutics, Roche, SirTLabs Corporation, and Teva Pharmaceuticals Inc. D.P. is a co-inventor on a patent pending application (US20190292130) submitted by Ramot at Tel Aviv University on 8 November 2016. The authors declare that they have no other competing interests.
Moving on to other promising ways to cull the population.
Typhoid-Plague Bivalent Vaccine
The combined F1-V fusion in the Ty21a carrier stimulates a robust immune response in mice.
The potential to combine the oral plague vaccine of this invention with FDA’s candidate oral anthrax vaccine exists, and would result in an easy-to-administer oral delivery system to streamline administration of the vaccine to large numbers of recipients in emergency situations.
What’s better than a plague vaccine? Plague + Anthrax with a Typhoid Topper, of course!
So there you have it, friends.
Two people got the plague, didn’t you see it on literally every news channel?
Oh and by the way, we’ve got these 100% AWESOME vaccines.
Roll up dem sleeves!
Most everyone learned about these diseases of history as horror stories, but hardly anyone gets the follow up they deserve. Dissolving Illusions should be required reading for everyone. The big threats are really poor nutrition, filthy living conditions, poor sanitation, and poor water quality.
The *entire world* could have gotten clean drinking water for a tiny fraction of what’s been spent on Covid and vaccines. Gates and his ilk would never fund something as impactful as that—no profit.
I suspect that the next major PsyOp — with Covid being a major PsyOp and the poisonous injections (touted as therapeutic/curative) being a major PsyOp — won’t have anything to do with a (so-called) “pandemic”. What exercises have already been run? A massive cyber attack. Has there been any recent Predictive Programming or Revelation of the Method of a major cyber attack. Why yes. The movie “Leave The World Behind”.
Your thoughts?